– Team 1.1 : Polarisation and binary dynamics in the nervous system (V. Bertrand).
Our aim is to determine how extracellular molecules can polarize tissues during development. To address this question we are using as a biological system a field of neuronal precursors in the C. elegans embryo and we are developing innovative quantitative imaging approaches to analyze the dynamics of ligands and receptors during the polarization process in vivo.

– Team 1.2 : Morphogenesis and cell compartimentation (A. Lebivic).
Our project aims at deciphering the role of Crumbs, a transmembrane protein, in the organization of the sub-apical acto-myosin cytoskeleton and in the remodeling of Adherens junctions in both Drosophila melanogaster in collaboration with the team of Thomas Lecuit and in human epithelial cells in culture. To this goal we will develop with the team of Pierre-François Lenne new optical and physical methods to study forces and Adherens junction organization.

– Team 1.3: Biomechanics of cell and tissue morphogenesis (T. Lecuit  , Coordinator).
The team will study the mechanisms of adhesion and force transmission by E-cadherin complexes. This will involve a combination of quantitative imaging in Drosophila epithelial cell cultures and embryos, mechanical and genetic perturbations. Collaborations with Team 1.2 and 1.4.

– Team 1.4: Cell and tissue physics (P.F. Lenne , Coordinator).
The team develops and applies quantitative approaches to study cell dynamics and cell mechanics during tissue  morphogenesis. The group will contribute to (i) the study of supramolecular organization and dynamics of adhesion  components at cell interfaces in vivo  and (ii) quantitative measurements/analysis of ligand-receptor interactions during tissue polarisation.

– Team 1.5: Immune response and development in Drosophila (J. Royet).
Our lab  is studying the interactions that are taking place  between bacteria and the gut epithelium using Drosophila as a model  system. In the context of the Labex, we shall study the in vivo consequences associated with bacteria detection and immune signalling pathway activation in enterocytes.

– Team 1.6 : Physical and Molecular Principles Governing Cytoskeletal Organization (A. Michelo, alphee.michelot@cea.fr).
Our team has two main objectives. Our first aim is to understand some of the basic physical and biochemical principles governing cytoskeletal organization (principally actin) in eukaryotic cells. Our second aim is to understand how cells use different actin networks to perform a variety of cellular functions.